Causes Of Immature Red Blood Cells?
I want to ask, do erythoblasts or immature red blood cells come out of the bone marrow? if there is an abnormality, what is it called?
Hello, good morning Vero.
The stages of erythrocyte / red blood cell formation (also known as eriropoiesis) occur in the bone marrow. Normally, in the bone marrow there is a maturation process from stem cells (stem cells) to erythroblasts then to normoblasts and finally to reticulocytes. These three types of cells are still immature red blood cells. After approximately 3 days in the bone marrow, reticulocytes will leave the bone marrow and enter the bloodstream in the peripheral blood vessels. In the peripheral blood vessels, reticulocytes will change (for 24-48 hours) into mature red blood cells.
Regarding your question regarding the condition of the presence of immature red blood cells (one of which is erythroblasts) coming out of the bloodstream, it generally indicates a pathological condition (abnormal). This condition is thought to occur due to increased erythropoiesis (the process of forming red blood cells), bone marrow damage (especially due to an inflammatory process or very low oxygen supply), or because of the very high need for red blood cells in blood vessels so that blood cells are immature was forced to come out of the bone marrow to the peripheral blood vessels.
Some of the medical conditions that can cause this condition include:
severe anemia (lack of hemoglobin in the blood)
thalassemia disease, which is a disorder of hemoglobin that does not function normally
malignancy of the bone marrow
conditions of lack of oxygen supply in the long term (hypoxemia)
sepsis (severe infection)
malignancy in blood cells
If you or your family experience this, consult a doctor who is an expert in their field for further treatment, yes .. (if adults can go to an internal medicine specialist, or if children can go to a pediatrician).
That's all, hope it helps.