Diabetes Drugs That Are Safe For Pregnant Women?

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want to ask, which of these drug options (glibenclamide, metformin, acarbose, tolbutamide, repaglinid) is safer for 4 months pregnant women suffering from gestational diabetes. The reason why? Thanks.

1 Answer:

Good evening, thanks for asking at HealthReplies.com. To answer your question, first you need to know that most drugs have passed the pregnancy classification by the FDA (Food and Drug Administration, a kind of BPOM-like body in America). The FDA classifies drug safety levels with the letters A, B, C, D, X and N. This classification is based on reporting drug side effects and studies conducted on a number of pregnant women and their fetuses, as well as on a group of tested animals.


The safest drug class for pregnant women at any age is labeled with the letter A, and the class of drugs that are the least safe and should not be given to pregnant women at any age is labeled with the letter X. Meanwhile, the N label indicates that the drug has not been labeled or not yet. there is supporting research. Other labels, namely B, C, D indicate a decrease in the level of security and it can still be given if in judgment, the benefits outweigh the potential losses.


That way, so far the drugs you mention have the following labels:


Glibenclamide, labeled C

Metformin, labeled B

Acarbose, labeled B

Tolbutamide, labeled C

Repaglinide, labeled C


So there is no A, but based on the data, among the safest ones are metformin and acarbose. However, what we need to tell you is that diabetes medication for gestational diabetes patients requires serious supervision and attention, because it depends on the severity and is different in each case. The mechanism of action of each drug that you mention is different so that its use varies. Do not buy this drug and do not use it without a doctor's supervision to avoid side effects that are much more detrimental to you and the fetus.


Check with your obstetrician and / or internist, and let your doctor determine the best treatment for you. Your job is not to choose drugs, but to do things that are more natural, such as following a healthy diet by eating vegetables, fruits, whole grains, low-fat and fiber-rich foods and drinks. You are also advised to do regular exercise according to gestational age, drink lots of water, and routine pregnancy control at an obstetrician. So, hopefully it answers your question.

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