Hepatitis B Drug Resistant?

Illustration of Hepatitis B Drug Resistant?
Illustration: Hepatitis B Drug Resistant? intechopen.com

Good evening, I want to ask if a person with hepatitis b who goes to treatment for a long time is resistant to the drug, what is the next good treatment, what will be the impact in the future? Thank you in advance

1 Answer:

Hello Nencydatu, Thank you for the question.

Hepatitis B is inflammation of the liver caused by hepatitis B virus infection. Long-term / chronic infection can cause progressive damage to liver cells as a result of the virus that replicates (grows / increases in number); which further causes cirrhosis or hepatocellular carcinoma. Currently available hepatitis B treatment (antiviral drugs) aims to reduce the amount of virus in the blood so that the likelihood of these complications is reduced. However, treatment with antiviral drugs is still possible to trigger hepatitis B virus mutations so that the virus becomes resistant to the drug. Currently, there are several antiviral drugs available on the market. If the sufferer is resistant to one drug, the doctor will usually choose another antiviral drug. Several studies have shown that the antiviral drug tenofovir disoproxil fumarate can be the drug of choice for treating patients with drug resistance. Of course, the choice of this drug must be in accordance with the examination of a specialist in internal medicine against the patient's condition. Please advise the patient to consult further with a specialist in internal medicine. If there is no treatment that can treat the sufferer's condition, the final step is to perform a liver transplant.

If a patient who is resistant to a drug is not treated with other antiviral drugs, the hepatitis B virus can continue to develop, damage liver cells and cirrhosis until liver failure can occur. Therefore, examination and supervision by a specialist in internal medicine is needed.

Hope this information is helpful.

Dr. Aloisia

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