How Aminoglutetimide Treats Hypercortisolism Due To ACTH Hypersecretion?
How aminoglutetimide treats hypercortisolism due to ACTH hypersecretion
Aminoglutetimid is an antagonist of corticosteroids or substances that work by inhibiting changes in the form of cholesterol into pregnolon, inhibiting the enzyme aromatase so that it inhibits the formation of steorid by the adrenal glands where one of them is cortisol production so that hypercortisolism can be reduced, preventing changes in the form of progesterone and hydroxy progestetrone to deoxicorticolone and deoksicorticol become cortisol and cortisone is also inhibited. Furthermore, it also inhibits cortisone to turn into aldosterone.
Aminoglutetimid is also indicated for several other treatments such as hypercortisolism due to tumors or malignancy in the adrenal glands, cushing's syndrome, breast cancer and prostate cancer. If needed it can also be added to physiological cortisol to maintain the balance of steroid hormones in the body so as not to cause functional disorders.
For more details, we recommend reading textbooks and related journals about the workings and pharmacology of aminoglutetimids on the body in greater depth to understand them.
May be useful,