Methotrexate (MTX)

Illustration of Methotrexate (MTX)
Illustration: Methotrexate (MTX)

excuse me doc, I want to ask you about methotrexate, I have read about individualizing dosages and MTX dose adjustments in RA patients, what do you mean by that?

1 Answer:

Hello Atiq, thank you for asking

Methotrexate is a type of drug used to treat cancer. Apart from cancer, this drug can also be used to treat rheumatoid arthritis (RA) and severe psoriasis and cannot be treated by other drugs. In RA, methotrexate is used in cases of severe, active, classical, or definite RA that does not show a positive response to usual treatment. This drug will reduce the symptoms of pain in RA, and inhibit disease activity and prevent joint damage.

Methotrexate is a type of drug whose use must be monitored closely by doctors, because this drug can cause serious side effects and endanger lives. This drug can cause disability in the fetus and the substance will go into breast milk, so it should not be used in pregnant and lactating women. So before using this medicine you should consult with an internal medicine doctor.

The widespread use of Methotrexate cannot be used just like that. Dosage adjustments are needed, which is the use of methotrexate which is tailored to the needs of patients with RA. Besides that, the dose of each person who uses methotrexate is not the same. There are indications or conditions that must be met if RA patients will be treated using this drug. These things are called individualization and adjustment in the use of methotrexate. The adjustment is called individualization because the dose changes are based on the patient's own body response.

In the use of this drug, the doctor will check and make sure the indications are appropriate and can be used or not. In addition, information is also needed about previous drug use or treatment that is being routinely carried out, because the use of methotrexate will cause negative interactions when taken with several types of drugs. When it is decided to use metotrexate, the doctor will carry out routine blood tests while on treatment because this drug can interfere with organ function and decrease the number of blood cells.

I hope this helps


dr. Sussy

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