Pregnancy Planning?

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Good afternoon, I want to ask … we will plan a pregnancy, but there are some concerns that land on me, because of the condition of a couple who has a history of (autism) in their family brother u0026amp; his younger brother experienced this and the second child was my (husband) who was free from it. In this condition I, as my wife, thank God there is no such history. Honestly, I was ” u0026amp; worried about this. What I asked about tips for overcoming this condition, how do I try to search google, indeed the recommended use of vitamin folate at a dose of 400 mcg (1 month before pregnancy u0026amp; 3 months of pregnancy ) is recommended. But what I am afraid of, because I feel a high risk so that the consumption becomes 5mg per day / 5000 mcg (which means 10X as much dong)? n n1. Is that true? n2. Is it the same as autism u0026amp; history NTD? N nPlease enlighten me, thank you

1 Answer:

Hello, good afternoon Puspitap.


Autism / ASD (Autism Spectrum Disorder) is a neurodevelopmental disorder that affects a child's ability to communicate, engage in social interactions, and behave. The exact cause of autism is not yet known, but there are several factors that are thought to play a role in causing this condition. These factors include:

heredity. Parents of a person with autism are at risk of having a child with the same disorder
exposure to alcoholic beverages or drugs (especially epilepsy drugs for pregnant women) during pregnancy
premature birth
the influence of other disorders, such as Down syndrome, cerebral palsy (brain paralysis), etc.


NTD and Autism are two different conditions. NTD (Neural Tube Defects) is a condition when the formation of defects in the neural tube. This neural tube will become the nerve for the fetus. Defects in the neural tube can cause several diseases, such as anencephaly, spina bifida, etc. Anencephaly is a condition in which the brain and skull of the fetus are not fully formed so that it does not allow the fetus to live outside the uterus, while spina bifida is a condition where a gap in the baby's spine is formed.

Consumption of folic acid (vitamin B9) is needed by women, both when planning a pregnancy, and when pregnant itself. The benefits of folic acid are numerous for pregnancy and for fetal development, not just for preventing autism. Folic acid plays an important role in preventing spina bifida (a gap in the spine), plays a role in fetal development, prevents brain defects, etc. The recommended dose is 400 micrograms a day. However, under special conditions, the dose required can be higher. These special conditions include: pregnant women who have deficiency (deficiency) of folic acid levels in their body, a dose of 5 mg per day is required and pregnant women who are at risk of neural tube defects (NTDs), the required dose is 5 mg per day.


Thus, if you do not have low blood folic acid levels and do not have the risk of NTDs, then the required dose is 400 mcg per day. You need to know that excess folic acid actually increases the risk of a child born with autism. A study shows that pregnant women with high folate levels during childbirth have a 2 times greater risk of having children with autism than mothers with normal folate levels.


We recommend that you consult a gynecologist about your concerns. The doctor will perform the examination and provide the appropriate follow-up according to your condition (including doses of folic acid and other substances that you will need during pregnancy and preparing for pregnancy).

I hope this helps.


Greetings, dr. Denisa

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