Side Effects Of Long-term Consumption Of Paracetamol?

Why can long-term PCT drugs cause hepatotoxics?

1 Answer:

Hello, thanks for the question.

Paracetamol is an analgesic or pain reliever that is widely used in society, this drug works by inhibiting the formation of prostaglandins, especially in the central nervous system. Paracetamol is metabolized in the liver and its metabolic products (metabolites) have the potential to be dangerous if used in excessive doses or for long periods. At therapeutic doses or normal doses, these harmful metabolites can be neutralized by glutathione to be non-toxic or harmless senyawayang and can be excreted through urine. However, in excessive and long-term doses, the production of these harmful metabolites exceeds the production of glutathione which serves to neutralize the toxins so that these metabolites are excessive in number and can cause reactions with normal liver cells that can cause liver cell damage. Therefore, although this drug can be purchased freely at a pharmacy, its use must be cautious and should be used as directed by a doctor, avoiding excessive use of drugs and without indication.


Thus, hopefully it helps.

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