Thalassemia Formula?

Illustration of Thalassemia Formula?
Illustration: Thalassemia Formula? scielo.br

I’m thalassemia major right? Will it pass to my first child or not? Please explain .. nThank you.

1 Answer:

Hello, thank you for the question for HealthReplies.com

Thalassemia is a genetic disease that is inherited with an autosomal recessive pattern. There are 2 types of chromosomes (genetic material in cells) in every human body cells, autosome (body chromosome) and allosome (sex chromosome). Humans have 22 pairs of autosomes and 1 pair of allosomes, so that in total humans have 23 pairs of chromosomes. These chromosomes were obtained 23 from the father and 23 from the mother.


The thalassemia carrier gene (HBB gene) is present in one of these 22 pairs of autosomes. For someone to have thalassemia major, the damage must be in these two genes. If your partner does not have thalassemia at all (meaning that both genes are normal), then your children will most likely experience thalassemia trait (mild thallasemia). If your partner has a thalassemia trait (meaning there is damage to one gene only), then there is a 50% chance that your child will experience thalassemia major and 50% chance that your child will experience thalassemia trait. If your partner also has thalassemia major (meaning there is damage to both genes), then your children will all develop thalassemia major as well.


The following is a picture of his genetic inheritance:


So much information from me, hopefully it will be enough to answer


dr. irna cecilia

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