The Cause Of Increased Reticulocyte Levels?

Illustration of The Cause Of Increased Reticulocyte Levels?
Illustration: The Cause Of Increased Reticulocyte Levels?

I am winda 17th. My reticulocytes are 2.9% even though there is no visible bleeding. Is that normal?

1 Answer:

Hello Winda.

Thank you for the question.

Reticulocytes are young red blood cells or immature erythrocytes. The level is 1% of human erythrocytes. The normal value of reticulocytes in the blood is 0.5% - 1.5%. Reticulocytes are produced by human bone marrow in response to anemia. There are many causes for increased levels of reticulocytes in the body, such as

Erythrocyte rupture or hemolytic anemia. In this condition the patient often presents with yellowishness of the eyes and body.
Response to therapies such as iron supplement therapy, vitamin B-12, or folic acid, supplementation to increase red blood cell production, or response to bone marrow transplantation.
Bleeding such as bleeding from fractures, internal organ bleeding, gastrointestinal bleeding, and prolonged menstruation.

Thus, not all increases in erythrocytes are associated with bleeding. Also, not all bleeding can be seen with the naked eye.

Referring to your previous question, the result of your blood test last month was microcytic hypochromic anemia with serum iron (SI) 102 ug / dL, TIBC 396ug / dL. Albumin 4.4g / dL. Globulin 3.6g / dL. Total 1.0 Direk 0.4mg / dL Indirek 0.6mg / dL. Stool brown, odor: characteristic, blood: negative, consistency: mushy, mucus: negative. Leukocytes: 2-3, erythrocytes 1-2 / TBSA.

As my colleague explained earlier, that this may be related to the complaints you experienced 1 year earlier. But I will try to explain back one by one your laboratory results. (can be read at: lab test results)

Microcytic hypochromic anemia can be caused by a deficiency of certain nutrients such as iron in iron deficiency anemia or bleeding. This type of anemia is also found in people with blood clotting disorders such as Thalassemia and Hemophilia. People with microcytic hypochromic anemia will be examined for SI and TIBC to see if there is a possibility of suffering from anemia due to iron deficiency. In your laboratory results, there are no abnormalities in the results of iron levels in the body.

Globulin is a protein in the blood. Globulin plays a role in liver function, blood clotting, and fighting germs that cause infection. Normal globulin ranges from 2.3 g% - 3.2g%. From your laboratory results Globulin 3.6g%. Increased globulin levels may indicate infection, inflammatory processes, cancer, and autoimmune diseases.

On the stool examination, there were leukocytes and erythrocytes in laboratory or invisible to the eye. This indicates an inflammatory process in your digestive tract and the presence of invisible bleeding.

From the overall lab results that you conveyed earlier, if there is an increase in reticulocytes even though there is invisible bleeding it is a thing that can be found. However, if you experience this continuously, then you will experience severe anemia and it can be fatal.

So, it is highly recommended to consult an Internal Medicine Specialist, so that the cause can be identified with certainty.

Hopefully my explanation can answer the question.


dr. Kresnawati Wahyu Setiono

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