The Function Of The HPL Hormone For The Fetus And Its Effects If It Is Deficient?
What is the function of the HPL hormone for the fetus and if the hormone deficiency is what is the impact?
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HPL or human placental lactogen or also known as human chorionic somatomammotropin is a hormone produced by syncytiotrofiblasts in the placenta. This hormone can be detected in the blood circulation of pregnant women at 6 weeks of gestation and will continue to rise slowly until it peaks at 34 weeks of gestation.
This hormone has the main function of regulating glucose metabolism in the body of pregnant women to provide good nutrition for the baby in the womb. This hormone will inhibit the work of insulin in the mother's body cells, inhibit the entry of glucose into the cells, thereby increasing blood glucose levels in the mother. This increase in the mother's blood glucose levels will cause more glucose to enter the baby's bloodstream to help meet the baby's nutritional needs. When a pregnant woman is fasting, this hormone will increase the occurrence of lipolysis (the breakdown of fat to free fatty acids for body metabolism) which will ensure that the baby still gets adequate nutrition even though no food is entering the mother's body.
Lack of this hormone in pregnancy (usually due to genetic defects) can cause stunted growth of the baby in the womb (the baby becomes small), but women who experience this hormone deficiency can still get pregnant and give birth normally.
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