The Link Between Being Overweight And Ovarian Cancer?
Why is being overweight at risk for developing ovarian cancer?
Thank you for your question
Excess body weight is associated with an increased risk of ovarian cancer. Excess weight here means the condition of obesity which is assessed based on a person's body mass index (BMI). Actually the mechanism of the occurrence of any cancer is not clearly known, but it is considered various changes in the function of a person's body cells, so that these cells become malignant and attack healthy body cells. Actually obesity is not limited to ovarian cancer, but is associated with the condition of the appearance of cancer in general. What you need to pay attention to is that this obesity condition only increases the risk for cancer in a person, so it doesn't always have to be that people who are obese will definitely experience cancer. But when compared with people who are not obese, the incidence of cancer is statistically more in those who are obese. Regarding this obesity condition itself, there are indeed several theories that explain why cancer, including ovarian cancer can be affected by this obesity condition, where this obesity condition is associated with an increase in the amount of fat in the body. This excessive increase in body fat is considered to affect the appearance of cancer through several possibilities, especially related to the production of hormones and other growth factors that can affect cell growth in excess, specifically:
Fat tissue will increase the production of the hormone estrogen (female hormone) in large quantities, where this hormone is considered to be associated with increasing the risk of breast cancer, endometrial cancer, and several other cancers. People who are obese usually have high levels of the chemical insulin and insulin-like growth factor-1 (IGF-1) in the blood, which are thought to trigger tumor growth. Fat cells will produce hormones called adipokines, which will stimulate or inhibit cell growth. People who are obese often experience inflammation or inflammation in the body that is chronic (occurring over a long period of time), this excessive inflammation is also associated with an increased risk of cancer. So, in general, a person needs to adjust their lifestyle and food consumption patterns to avoid obesity, which is one of the risk factors for cancer. Adequate rest, physical activity (exercise) on a regular basis and eating arrangements (regular meal times and avoiding the assumption of excessive fat) will certainly help prevent someone from becoming obese.
Hope this answer helps you.
dr. Aldy Valentino