The Mechanism Of Pyazinamide OAT And Ethambutol?
Slmt mlm doc Sorry to bother me I want to ask about the mechanism of action of pyazinamide OAT u0026amp; ethambutol in the body which can trigger gout
Good morning, thanks for asking at HealthReplies.com. Pirazinamid and ethambutol are the names of drugs that are often used to treat tuberculosis (OAT / Anti-Tuberculosis Drugs) and are included in the class of antibiotic drugs. As with other antibiotics, this drug requires a doctor's prescription to take it, and may not be purchased, used, added or reduced the dose without doctor's recommendation.
Regarding your question, indeed these two drugs should be used with caution for those who have gout and can even have side effects in the form of gout. This happens because according to research in 2014, pyrazinamide also has the ability to hold uric acid in the body, causing 80% more uric acid to settle in the body at a dose of 300 mg per day. While ethambutol causes high uric acid conditions by reducing the ability of the kidneys to get rid of uric acid, although it is not as strong as pyrazinamide.
Apart from that, once again, side effects must be present in every drug made by humans. When faced with conditions like this, again it is the doctor's decision to assess the possibility of good and bad, and if this drug is still given to the patient, it means that the doctor has assessed that there will be more good benefits that can be taken by the patient than the adverse effects. So, hopefully answering your question.