The Mechanism Of The Occurrence Of Turner Syndrome In Humans?
, I want to ask, how does Turner syndrome damage the X chromosome specifically how it works, thank you ..
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Turner syndrome is a condition that occurs when a woman (who should have chromosomes 46, XX) loses part or all of one of her X chromosomes (so that it becomes 45, X or 45, X0). This condition can be detected since the fetus is still in the womb or after it is born, even as an adult. Symptoms that appear usually include:
When the fetus is still in the womb: there is a collection of fluid behind the neck or other abnormal body parts, heart or kidney abnormalities When the baby: large neck, small ears, broad chest with a long distance between the nipples, high palate, short nails and pointing upward, swollen hands and feet, stunted growth (especially from height), heart problems, hairline on the back of the head is low, small lower jaw, short fingers and toes As adults: stunted growth, short stature, growth of sexual organs secondary is obstructed, menstrual cycles stop very early, fertility disorders. Various studies have been conducted to determine the causes of chromosomal disorders that cause Turner's syndrome. The conclusions from these various studies mostly refer to disorders of sperm cells, eggs, or also obstacles to fetal development in the uterus. There is also one gene that is thought to play an important role in causing the manifestations of Turner syndrome, namely the SHOX gene, which is important in regulating bone development and growth. However, the exact mechanism of this is not clear until now.
That's all for our explanation. For more details, please consult directly with the nearest doctor or biomolecular expert.
I hope this helps.