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, what is the normal level of serum urinary 3 hydroxyisovaleric acid?

1 Answer:

Hello Nur Izzah, Thank you for the question.

Biotin is one of the important vitamins needed by the body that is obtained by consuming certain food sources because the body cannot produce this vitamin. This vitamin can also play a role in glucose metabolism, fatty acid formation, and the formation and breakdown of branched-chain amino acids. Biotin can be obtained from food sources namely egg yolks, liver, and several types of vegetables. Biotin has benefits for preventing hair loss, maintaining healthy skin, eyes, kidneys and central nerves, and avoiding insomnia. In addition, biotin is also one of the important nutrients for pregnant women and fetuses. Several studies have shown that biotin deficiency can cause cleft lip and shorter leg size. At present, to determine the status of biotin levels in the human body is by measuring the excretion of 3-hydroxyisovaleric acid in urine (a normal residual metabolite found in urine), plasma concentrations of 3-hydroxyisovaleryl-carnitine (3HIA-carnitine), and levels of 3HIA- Carnitine in urine. This substance is normally found in urine with levels of 3.3-12 mmoL / mol creatinine. Increased levels of 3HIA in the urine can indicate deficiency in the early stages of biotin. Sorry I did not find any 3HIA serum examination but what has been used is the 3HIA-carnitine plasma examination (normal levels 0.005-0.018 micromol / L). You can try again to confirm with the doctor who recommended this examination or for the results of the normal reference value you can usually find out in the laboratory examination results sheet in the column "reference value / normal value". If you still have further questions, you can re-create a new conversation, yes.

Hopefully this information helps you.

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