TPHA Examination Results Are Negative?
I want to ask, if the test results at the puskesmas show the TPHA negative. What does it mean? Are these results accurate?
Good evening, thanks for the question
TPHA examination (Treponema Pallidum Haemagglutination Assay) is included in serological examination to diagnose sexually transmitted infections, namely syphilis due to Treponema pallidum.
In general, syphilis serological examination consists of two types, namely:
1. Non-treponema test
Included in this category are the RPR (Rapid Plasma Reagin) test and VDRL (Venereal Disease Research)
Laboratory). This test is useful for detecting non-specific antibodies to syphilis. However, these antibodies can also occur in other conditions, such as acute viral infections and autoimmune diseases. Therefore this examination is non-specific so that it can show false positive results.
2. Treponema test
Included in this category are the TPHA (Treponema Pallidum) tests
Haemagglutination Assay), TP Rapid (Treponema Pallidum Rapid), TP-PA (Treponema Pallidum Particle Agglutination Assay), FTA-ABS (Fluorescent Treponemal Antibody Absorption). This check is useful for detecting antibodies that are specific to treponema. Therefore this examination is rare
give false positive results. The treponemal test only shows that a person has been infected with syphilis, but can not indicate whether someone is having an active infection.
If the results of the TPHA are negative, it can be concluded that the results are conclusive, which means that they are infected with T. pallidum. If the previous non-treponemal (RPR) examination was positive while the results of the TPHA examination were negative then it was concluded that the positive result was false.
If so, it is classified as syphilis negative, so there is no need to be given treatment and it is advisable to re-examine again 3 months later.
That's all, hope you can help