Treatment Of Grade 1 Malignant Breast Tumors?
hello …. good afternoon ……. I want to ask, tests for malignant tumors in my breast gread 1 results of immunohistochemical examination have come out and the results are ER: negativePR: positive (positive in 20-50% of tumor cells w moderate-strong intensity) HER2: negative Ki67: positive (positive in less than 20% of tumor cells) what does that mean ?? thanks, mhon the answer
Hello Noor Anissah, thank you for asking.
In the case of benign or malignant tumors (cancer), after biopsy or after removal of the tumor, tumor tissue samples will be sent to the laboratory for anatomic and immunohistochemical pathology examination.
Immunohistochemical examination (CPI) is a type of microscopic examination that uses a dye outward in a cell sample, to see certain types of proteins. In a cell, there are hundreds or even thousands of types of constituent proteins. In certain types of tumor cells, the production of some of these proteins will increase or decrease. Certain types of proteins can be used as markers for tumor cells. That is, for example there is a sample of tumor A, then the tumor cell A, there will be an increase in protein X, Y, and Z. If the examination of a cell sample apparently did not get an increase in protein X, Y, and Z, then the sample does not contain tumor cells A.
In breast cancer CPI, ER (estrogen receptor), PR (protein receptor), HER2 (human epidermal growth factor receptor 2), and Ki67 (proliferation marker), are markers in the form of proteins that can describe the type of cancer and possibly cancer the relapse (relapse). A positive HER2 value and a positive Ki67 value, indicate the possibility of cancer relapse.
The results of the CPI examination are not intended to be understood by the patient, so it's only natural that you are confused. These results are a means of communication between the PA doctor and the surgeon who is handling your case. So that the person who has the right to interpret the results of the CPI examination is the doctor who treats you. You do not have to understand each of these protein functions, but the doctor will explain in general with language that is easy to understand, what is the overall purpose of the CPI examination results. Therefore, you must bring back the CPI results to be interpreted by a doctor. The doctor will adjust the grade / stage of your malignant tumor with CPI results, then determine the follow-up actions.
Such information from me. Hope it can be useful. Regards.