Whether A CPI Check Will Have A Different Result From A Biopsy?

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Good afternoon, I want to ask! R nMy brother was convicted of malignant lymphoma and had done a tissue sampling procedure and then a biopsy and something (I forgot) was taken in the spinal cord. And yesterday the results of the PA had dropped, but the results of the PA stated that the tissue did not show signs of malignancy, and the results of the spinal cord were negative. Why is that? Even though when the pet scan the glands had spread, a biopsy had to be done immediately because the doctor’s diagnosis was malignant (malignant lymphoma) but why after the biopsy the PA results were different? because the doctor is curious to do a CPI check, now can the check change his previous status? Or does it remain unchanged? R nAccording to HealthReplies.com, if the PA results are normal / negative, will all the results remain the same? If bs changed, what caused the change? For example, from the equipment or the sample there is a problem or what? Please provide a complete explanation, because I really need advice from HealthReplies.com. Thank you

1 Answer:

Hello, Rara Rani Rania, thank you for asking HealthReplies.com.


Lymphoma is a cancer that appears in the lymphatic system (one of the body's defenses consisting of lymph nodes and vessels). Malignant lymphoma is said if the cells have the ability to spread to other tissues. A series of examinations and tests must be done to diagnose a disease, including lymphoma. To diagnose lymphoma, it is necessary to take anamnesis (interview about everything related to complaints and symptoms), physical examination, and investigations. The necessary supporting examinations include complete blood tests, ultrasound, x-rays, biopsy (examination of the tissue under a microscope), to other further tests such as CPI / immunohistochemistry. In patients who have abnormal lumps on the body, a biopsy is the standard diagnosis to see the type of cell, where the cells come from, and whether the cell is benign or malignant.


Immunohistochemistry is a further test of biopsy to detect / see the nature of the protein (antigen) present in tissue cell samples. Each tumor cell has a specific antigen that can indicate where the cell came from. This test is used to diagnose the nature of cells, and can distinguish the type and organ from which the cells originate. CPI is often performed to confirm the results of previous biopsy tests, so that the results can be the same or different from previous biopsy. What can make the difference between a CPI result and a regular biopsy is the examination technique. In a biopsy with IHK, there will be a process in which antibodies will bind specifically to certain antigens in the tissue sample. If the antigen content contained in tumor cells can be identified, then a diagnosis, treatment plan can be determined, and the possibility of recovery.


Consult the treating doctor for a diagnosis decision and a treatment plan. Follow a series of therapies recommended by your doctor for optimal results. Maintain health with regular control from the treating doctor according to the recommendations, regular consumption of medicines recommended by the doctor, adequate daily nutritional and fluid needs, avoid smoking and alcohol, and adequate rest.


That's all, hopefully it's useful.

Greetings, dr. Sarah Rizqia.

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