Why Do People With Acute Myeloid Leukemia Develop A Hematoma In The Right Thigh Area?
want to ask, what is the relationship between hematoma and acute myeloid leukemia? is it due to infiltration of blast cells or due to external trauma? Thank you in advance.
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Leukemia (blood cancer) occurs when cells in the spinal cord (especially white blood cells) proliferate abnormally, excessively, and get out of control. Based on the onset and type of abnormal cells produced, leukemia is classified into 4, namely AML (acute myelogenous leukemia), ALL (acute lymphocytic leukemia), CML (chronic myelogenous leukemia), and CLL (chronic lymphocytic leukemia). AML occurs when DNA damage in the cells that make up the spinal cord causes an overgrowth of myeloblast cells that cannot function properly. The exact cause of this DNA damage is not yet clear. However, it is predicted that exposure to radiation, certain chemicals, and chemotherapy can increase the risk of this disease.
AML sufferers can experience a variety of complaints, such as prolonged fever, bone aches, weakness, fatigue, shortness of breath, pallor, prone to infection, and also abnormal bleeding symptoms, such as easy bruising, nosebleeds, bleeding gums, and so on.
Maybe what you mean is, why people with AML can experience bruising (hematoma). Bruises are usually the result of bursting of blood vessels under the skin. The cause is due to reduced production of platelets (thrombocytes) which occurs due to being pushed by the proliferation of white blood cells in the spinal cord. As a result, even minimal injury (which sufferers often do not realize) can cause bleeding that takes a long time to heal, namely because the blood clotting process is disrupted.
AML sufferers should control their condition to a specialist in internal medicine. With a comprehensive examination, including blood tests, spinal cord examination, lumbar puncture, and DNA testing, doctors are usually able to determine the extent of disease progression as well as the best treatment to treat it. Usually, AML treatment can be done through several therapeutic modalities, such as chemotherapy, targeted therapy, administration of anti-cancer drugs, to spinal cord transplantation. In general, people with AML have the smallest potential for recovery compared to other types of leukemia (5 years survival rate is only around 27%). However, the potential for this cure can vary depending on the progress of the disease, age, the treatment given, the patient's responsiveness to treatment, and the patient's general health condition.
Hope it helps ..